INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE [ 2018 - 2021 ]

Research Grant

Researchers: Prof Grant Drummond (Principal investigator) ,  A/Pr Ashley Mansell ,  Dr Antony Vinh ,  Prof Christopher Sobey ,  Prof Michael Hickey

Brief description Chronic kidney disease (CKD) is a major health problem. There is no cure for CKD and current therapies merely slow its progression. Thus for many patients, dialysis or kidney transplant is an inevitable outcome. We have evidence that a protein called interleukin-18 (IL-18) is a key mediator of kidney damage in CKD. Here we will explore how IL-18 causes kidney damage and whether IL-18 may be used as a diagnostic for early detection of CKD, and a target for more effective therapies to treat CKD.

Funding Amount $AUD 1,017,386.76

Funding Scheme Project Grants

Notes Standard Project Grant