grant

Induction of senescence in cells that use the Alternative Lengthening of Telomeres (ALT) mechanism [ 2010 - 2012 ]

Also known as: Causation of permanent growth arrest in cancer cells that use the ALT mechanism for unlimited growth

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/633265]

Researchers: Prof Roger Reddel (Principal investigator)

Brief description Approximately 10-15% of all cancers depend on Alternative Lengthening of Telomeres (ALT) for their continuing growth. A key aspect of many successful cancer treatments is that they force cancer cells to undergo a form of permanent growth arrest called senescence. In this study we will investigate characteristics of ALT-positive cancer cells that may make them especially vulnerable to senescence. This may be exploited in the future as a therapeutic strategy for cancers that depend on ALT.

Funding Amount $AUD 474,048.32

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857