Induction of antigen-specific humoral tolerance by rAAV-mediated delivery of CTLA4-Ig-antigen fusion molecules [ 2008 - 2010 ]

Research Grant

Researchers: Prof Ian Alexander (Principal investigator) ,  Dr Alex Bishop

Brief description There are many medical situations where immune suppression is required. Available methods lack specificity and risk infection, drug-related side-effects and cancer. We have discovered a novel way of suppressing immunity such that only unwanted responses are eliminated. This involves virus-mediated delivery of antigen fused to CTLA4-Ig. We plan to test this strategy in the context of gene therapy, to work out how it works and to optimise the approach. Success will have broad health implications.

Funding Amount $AUD 524,456.94

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant