grant

Improving the use of chemotherapy by targeting the inflammatory response [ 2010 - 2013 ]

Also known as: Impact of tumours on drug clearance and toxicity in cancer chemotherapy

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/632848]

Researchers: Prof Stephen Clarke (Principal investigator) ,  A/Pr Andrew Katsifis ,  A/Pr Graham Robertson ,  Prof Andrew Mclachlan ,  Prof Mark Baker
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Brief description Patient differences in clearance of anti-cancer drugs have a major impact on the success of chemotherapy. Benefit is lost if the drug is cleared too rapidly, while slow elimination causes toxicity. We will use well characterised mouse models that mirror the human situation to study the causes and effects of reduced drug metabolism in cancer. The data will guide future human studies that will result in improved diagnostic and therapeutic interventions to improve the tolerance of chemotherapy.

Funding Amount $AUD 570,876.85

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Medical and Health Sciences | Oncology and Carcinogenesis | Oncology and Carcinogenesis Not Elsewhere Classified | cancer | cancer chemotherapy | cytokines | drug clearance | drug disposition in disease states | drug metabolism | hepatic gene regulation | human pharmacology | pharmacokinetics | toxicity |
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