Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity. [ 2018 - 2020 ]

Research Grant

Researchers: Prof Justin St. John (Principal investigator) ,  Dr Matthew Mckenzie ,  Dr Patrick Western ,  Prof Luk Rombauts

Brief description Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.

Funding Amount $AUD 680,259.34

Funding Scheme Development Grants

Notes Development Grant