Improving muscular dystrophy by targeting the ADAMTS5 metalloproteinase [ 2014 - 2016 ]

Research Grant

Researchers: A/Pr Shireen Lamande (Principal investigator) ,  A/Pr Jason White ,  Prof John Bateman

Brief description Muscular dystrophy is a devastating childhood disorder. There is no cure and no effective therapy to stop the disease progressing to early death. Our pilot data show that muscular dystrophy in a mouse model is dramatically improved when the Adamts5 gene is inactivated. ADAMTS5 is an enzyme that remodels the extracellular matrix around cells. This suggests that inhibiting ADAMTS5 may be a new way to treat muscular dystrophy. We will test this idea in mice with muscular dystrophy

Funding Amount $AUD 658,570.98

Funding Scheme Project Grants

Notes Standard Project Grant