IMPAIRED REGULATION OF CYTOCHROMES P450 DURING THE EVOLUTION OF HEPATIC STEATOSIS [ 2000 - 2002 ]

Research Grant

Researchers: Prof Michael Murray (Principal investigator)

Brief description The accumulation of fat in liver is a common problem in early liver injury caused by alcohol, certain drugs and diseases like diabetes. When this occurs the fats can change the amounts of a number of genes and proteins in liver. Cytochrome P450 proteins insert an activated form of oxygen into chemicals, including drugs and fats. In the process, however, some of these activated chemicals can damage surrounding tissues. This project will study the details of how the levels of cytochromes P450 are altered when fat accumulates in liver. The findings may suggest ways in which normal levels of cytochromes P450 can be restored and how to minimise the injurious effects of activated chemicals in liver.

Funding Amount $AUD 186,740.29

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant