grant

Impaired mitochondrial energy metabolism and the therapeutic activity of Cu(atsm) in age and age-related neurodegenerative disease [ 2014 - 2016 ]

Also known as: Harnessing the consequences of impaired mitochondrial energy metabolism to treat the symptoms of age-related neuronal decline

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1061550]

Researchers: A/Pr Peter Crouch (Principal investigator) ,  A/Pr Paul Donnelly ,  Dr Blaine Roberts

Brief description Cognitive function and locomotor ability decline due to advanced age and disorders such as motor neuron disease, Alzheimer’s and Parkinson’s disease. We have identified a treatment that attenuates these symptoms of age and disease in mice, thus extending the healthy lifespan of the animals. This project will investigate the mechanisms by which the treatment works, thereby advancing our understanding of the causes of cognitive and locomotor decline and the development of preventative treatments.

Funding Amount $AUD 689,823.94

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Medical and Health Sciences | Neurosciences | Neurology and Neuromuscular Diseases | age-related | amyotrophic lateral sclerosis | copper | energy metabolism | mass spectrometry | mitochondria | mouse models | neurodegenerative disorders | targeted therapy | therapeutic agents |
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