Impact of phasevarions of non-typeable Haemophilus influenzae on otitis media pathobiology and vaccine development. [ 2012 - 2014 ]

Also known as: The impact of a novel gene regulation system in the bacterial pathogen Haemophilus influenzae on the infectious process of middle ear infections and on vaccine development.

Research Grant

[Cite as]

Researchers: Prof Michael Jennings (Principal investigator) ,  Prof Lauren Bakaletz

Brief description Otitis media (OM), or middle ear infection, is a prevalent pediatric disease worldwide. Haemophilus influenzae causes 40% of acute OM cases, and most chronic OM and recurrent OM. There is a urgent need for vaccines to prevent OM. Our discovery of a novel genetic switch gives new insights into OM and the change from asymptomatic colonization to OM. The role of this switch on virulence in several dominant strains, and the impact on current and future candidates will be studied.

Funding Amount $AUD 613,124.15

Funding Scheme Project Grants

Notes Standard Project Grant

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