Impact of islet beta cell heparan sulfate in Type 2 diabetes [ 2014 - 2016 ]

Research Grant

Researchers: A/Pr Charmaine Simeonovic (Principal investigator) ,  Prof Stefan Bornstein ,  The Australian National University (Managed by)

Brief description Type 2 diabetes (T2D) is a chronic metabolic disease which ultimately leads to the death of insulin-producing islet beta cells, elevated blood sugar levels and daily insulin injections. Since beta cells require the complex sugar heparan sulfate (HS) for survival, we will investigate whether beta cell failure in T2D results from defective HS production. HS replacement will be evaluated as a new therapeutic strategy for preserving beta cell function and preventing the need for insulin injections.

Funding Amount $AUD 576,777.77

Funding Scheme Project Grants

Notes Standard Project Grant