Impact of Influenza A infection on T cell-mediated immunity to pulmonary tuberculosis. [ 2011 - 2013 ]

Research Grant

Researchers: Prof Warwick Britton (Principal investigator) ,  A/Pr James Triccas ,  A/Pr John Stambas ,  Dr Manuela Florido

Brief description Tuberculosis is a leading cause of death worldwide and there is an urgent need to develop better anti-TB vaccines. Infection with respiratory viruses may reduce memory T cell responses to M. tuberculosis (Mtb). This project will investigate if Influenza A infection reduces memory anti-tuberculosis T cell responses in mice previously exposed to Mtb or BCG. We will then use influenza viruses engineered to carry parts of Mtb proteins to boost anti-Mtb T cell responses and the protective effect of BCG.

Funding Amount $AUD 488,058.78

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant