grant

The impact of the changes in levels of adhesion molecules NCAM2 and DsCAM on synapse formation and function: implications for Down syndrome [ 2011 - 2015 ]

Also known as: Investigation of the mechanisms via which abnormal levels of brain proteins lead to brain malfunction in Down syndrome

Funded by National Health and Medical Research Council
Managed by University of New South Wales
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1011478]

Researchers: Dr Vladimir Sytnyk (Principal investigator)

Brief description Down syndrome (DS) results from triplication of chromosome 21 and leads to mental retardation, molecular mechanisms of which are not understood. We found that two proteins, NCAM2 and DSCAM, encoded at chromosome 21 are highly expressed in synapses. Synapses are specialized contacts between neurons which allow neurons to process information in the brain. In this project we will test a hypothesis that changes in NCAM2 and DSCAM expression result in synapse abnormalities observed in DS.

Funding Amount $AUD 334,053.95

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Cellular Nervous System | Down syndrome | Medical and Health Sciences | Neurosciences | adhesion molecules | neurons | protein characterisation | synapse formation |
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ACN 633 798 857