grant

The immunoregulatory domains and binding interactions of human respiratory syncytial virus non-structural proteins [ 2008 - 2010 ]

Also known as: Regulation of immune response by RSV proteins

Funded by National Health and Medical Research Council
Managed by The University of Queensland
Managed by University of Queensland
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/511020]

Researchers: A/Pr Kirsten Spann (Principal investigator) ,  Prof Jeffrey Gorman

Brief description Human respiratory syncytial virus (HRSV) is the leading cause of lower respiratory tract disease in infants and yet there are no vaccines available. HRSV exacerbates disease by interfering with the innate immune response. We aim to establish the mechanism by which this occurs by identifying the cellular-viral protein interactions involved, and by identifying the specific regions of the viral proteins responsible. This information will allow targeted vaccines and antivirals to be developed.

Funding Amount $AUD 484,051.08

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Applied Immunology (Incl. Antibody Engineering, Xenotransplantation and T-Cell Therapies) | Biomedical and Clinical Sciences | Immunology | antiviral | antiviral therapy | immunocompromised patients | microbiology-virology | molecular biology | protein-protein interactions | proteomics | respiratory diseases in children | respiratory syncytial virus | viral bronchiolitis |
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