Immunogenicity of dendritic cell nanovesicles [ 2018 - ]

Research Grant

Researchers: Prof Jonathan Sprent (Principal investigator)

Brief description Cancer immunotherapy by “checkpoint blockade” boosts the immune response and leads to tumour rejection in some patients. To improve immunotherapy, information will be sought on the capacity of membrane vesicles prepared from dendritic cells (DC) to stimulate immune cells (T cells) in mice and elicit tumour rejection. Experiments are proposed to trace the fate of the vesicles after injection and improve tumour rejection by combination with checkpoint blockade and addition of cytokines.

Funding Amount $636,978.00

Funding Scheme Project Grants

Notes Standard Project Grant