Immunodominance and protective immunity in the context of a complex host-pathogen system. [ 2014 - 2018 ]

Research Grant

Researchers: Prof Denise Doolan (Principal investigator) ,  Dr Nadine Dudek ,  Prof Anthony Purcell

Brief description In experimental infection models with simple organisms, pathogen-specific immune responses recognize only a small fraction of potential epitopes encoded by the genome. This phenomenon is termed immunodominance. We propose the first comprehensive study of immunodominance in humans in response to a complex pathogen, the Plasmodium parasite that causes malaria. This will provide valuable new knowledge of host-pathogen immunity and facilitate rational vaccine design.

Funding Amount $AUD 899,832.69

Funding Scheme Project Grants

Notes Standard Project Grant