Immune Regulation, Effector Function and Human Therapy [ 2007 - 2011 ]

Research Grant

Researchers: Prof Joseph Trapani (Principal investigator) ,  Prof Dale Godfrey ,  Prof Mark Smyth ,  Prof Miles Prince ,  Prof Ricky Johnstone

Brief description The immune system plays an important role in protecting the host from viral and bacterial infections, and inhibits cancer onset and progression. Immune processes proceed through specialised cells in conjunction with soluble factors such as inteferons and interleukins. These soluble factors can regulate the activities of immune cells, and inhibit the growth and survival of aberrant (virus infected, cancer) cells. Unfortunately, the immune system can sometimes lose specificity and attack the host, resulting in autoimmune diseases such as diabetes. This research team has played a vital role in characterising the specific activities of immune cells and the associated factors. Importantly, they are deciphering the intricate communication networks of these immune components and dissecting their modes of action. By understanding these complex processes, the team aims to harness the unique therapeutic properties of our own immune system and translate their findings into the clinic. The team is developing new immune-based therapies for use, either alone or in combination with existing chemotherapies to fight debilitating human diseases such as cancer and autoimmune disease.

Funding Amount $AUD 11,474,345.63

Funding Scheme Programs

Notes Program Grant