The immune modulatory function of chondroitin sulphate A in placental malaria: protecting the fetus, promoting the parasite? [ 2014 - 2018 ]

Research Grant

Researchers: Dr Louise Randall (Principal investigator) ,  A/Pr Joanne Said ,  Prof Stephen Rogerson

Brief description Pregnant women and their babies are susceptible to placental malaria infection. Malaria parasites infect the placenta by binding to chondroitin sulfate A (CSA). CSA levels increase in normal pregnancy. Studies suggest that CSA can suppress immune cell function. This study will look at the immune modulating function of CSA during pregnancy and placental malaria. CSA may act as camouflage, hiding the malaria parasite from immune cells. This may be a novel immune evasion pathway.

Funding Amount $AUD 529,206.95

Funding Scheme Project Grants

Notes Standard Project Grant