IL-22 as a Suppressor of Pancreatic ?-Cell Stress and a Treatment for Diabetes [ 2015 - 2018 ]

Research Grant

Researchers: Dr Sumaira Hasnain (Principal investigator) ,  Prof Michael Mcguckin (Principal investigator) ,  A/Pr Allison Pettit ,  A/Pr Jonathan Whitehead ,  Prof Jeff Coombes
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Brief description Type 2 diabetes occurs when pancreatic beta cells fail to produce enough insulin to control blood sugar levels. We have discovered that the IL-22 protein produced by immune cells protects beta cells from stress. Diabetic mice given IL-22 show restored control of blood sugar levels. The proposed research will take steps to safely introduce IL-22 based therapy into the clinic and gain a deeper understanding of the mechanisms of action of IL-22.

Funding Amount $AUD 854,490.62

Funding Scheme Project Grants

Notes Standard Project Grant