IGF-1 AS A THERAPEUTIC AGENT: HOW DOES IGF-1 AFFECT OXIDATIVE STRESS IN DYSTROPHIC AND AGED SKELETAL MUSCLE? [ 2008 - 2010 ]

Research Grant

Researchers: Prof Miranda Grounds (Principal investigator) ,  A/Pr Thea Shavlakadze ,  Dr Peter Arthur

Brief description Loss of skeletal muscle mass (wasting) and function occurs in many clinical conditions, including muscular dystrophy, neuromuscular and inflammatory disorders, and also normal ageing. A growth factor (IGF-1) is a promising therapeutic as it increases protein synthesis. Muscle wasting (loss of protein) is also associated with increased oxidative stress. The project will evaluate the impact of IGF-1 on oxidative stress using genetically engineered mouse models of muscular dystrophy and ageing.

Funding Amount $AUD 545,243.38

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant