[Cite as http://purl.org/au-research/grants/nhmrc/513826]
Prof Miranda Grounds
Dr Peter Arthur
A/Pr Thea Shavlakadze
Brief description Loss of skeletal muscle mass (wasting) and function occurs in many clinical conditions, including muscular dystrophy, neuromuscular and inflammatory disorders, and also normal ageing. A growth factor (IGF-1) is a promising therapeutic as it increases protein synthesis. Muscle wasting (loss of protein) is also associated with increased oxidative stress. The project will evaluate the impact of IGF-1 on oxidative stress using genetically engineered mouse models of muscular dystrophy and ageing.
Funding Amount $AUD 545,243.38
Funding Scheme NHMRC Project Grants
Standard Project Grant