Identifying the site/s of modification on the human L-type Ca2+ channel protein isoforms during oxidative stress with reference to development of a therapeutic target [ 2011 - 2014 ]

Research Grant

Researchers: A/Pr Livia Hool (Principal investigator) ,  A/Pr Ben Corry ,  Dr Evan Ingley

Brief description A rise in calcium and free radicals in the heart are associated with the development of heart disease. We have good evidence that a protein in the heart muscle known as the L-type calcium channel mediates changes in calcium in response to free radicals. This proposal will identify how the channel function is altered by free radicals so that a therapeutic target can be designed to prevent altered channel function and development of heart disease during increases in free radicals.

Funding Amount $AUD 360,369.27

Funding Scheme Project Grants

Notes Standard Project Grant