Identifying the role of airway stem cells in maintaining lentiviral mediated gene expression for cystic fibrosis lung disease [ 2016 - 2018 ]

Research Grant

[Cite as]

Researchers: A/Pr David Parsons (Principal investigator) ,  A/Pr Ivan Bertoncello Dr Martin Donnelley Dr Timothy Kuchel

Brief description Cystic fibrosis (CF) is a progressive, chronic and debilitating genetic disease that casuses early death from lung disease. Although drug treatments for a few of the ~2000 CF mutations have appeared, only a genetic therapy can treat all CF mutation types. This project will assess whether a novel airway pre-treatment improves the level and duration of lentiviral gene transfer, and whether effective long-term gene expression is the result of transducing resident airway basal stem cells.

Funding Amount $AUD 836,567.28

Funding Scheme Project Grants

Notes Standard Project Grant

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