Identifying the relationship between biochemical markers and healing in chronic leg ulcers treated with compression [ 2006 - 2008 ]

Research Grant

Researchers: Prof Helen Edwards (Principal investigator) ,  Prof Damien Harkin ,  Prof Mary Courtney ,  Prof Zee Upton

Brief description Chronic leg ulcers are a significant cause of pain, immobility and decreased quality of life for 1 - 3% of the over 60 years age group. The condition is difficult to heal and commonly becomes a long term problem, costing the Australian health care system over $500 million - year. Additional costs to the community include loss of productivity and social support systems necessary for people with limited mobility. As the number of people aged over 65 years is expected to double in the next few decades, this problem will become increasingly significant. Most chronic leg ulcers are caused by venous disease, and compression bandage therapy is the accepted standard treatment. However, there is little information available on the cellular responses associated with compression treatment and how they promote wound healing. The project proposed here will examine the cellular responses to compression and investigate the relationships between these cellular responses and wound healing. Knowledge gained from the study will provide valuable information for improved techniques to promote wound healing, improved ulcer healing rates, informed decisions on wound care treatment, improved qualtiy of life and reduced health care costs.

Funding Amount $AUD 374,159.17

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant