Identifying regulators of the DNA damage response and tumourigenesis using C. elegans [ 2011 - 2014 ]

Also known as: Discovering mechanisms of cancer control in a simple model organism

Research Grant

[Cite as]

Researchers: Dr Hannah Nicholas (Principal investigator) ,  Prof Merlin Crossley

Brief description By the age of 85, one in two men and one in three women in Australia will develop cancer. Regrettably, not all cancers respond to current therapies. Recently a new mechanism that prevents certain cancers from responding to chemotherapy has been identified, involving a protein called HIPK. We are using a simple model system, the nematode Caenorhabditis elegans, to discover ways in which this block to successful cancer treatment can be overcome, with the view to developing new therapeutic agents.

Funding Amount $AUD 514,367.45

Funding Scheme Project Grants

Notes Standard Project Grant

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