Identifying the molecular basis of memory B cell function and human immunoglobulin E memory via Hyper Immunoglobulin E Syndromes [ 1/1/2021 - 2/28/2023 ]

Research Grant

Brief description Memory B cells generate rapid and potent antibody responses to known threats. The molecular basis for this is unknown, but defects increase the risk of infection, autoimmunity, and allergy. Autoimmunity and allergy are often mediated by a poorly understood antibody subclass, immunoglobulin E (IgE). My project will use emerging single-cell technologies to reveal the molecular mechanisms of antibody memory and IgE regulation, enabling the design of superior vaccines and immunomodulatory therapy.

Funding Amount $96,009

Funding Scheme Postgraduate Scholarships

Chief Investigator Karrnan Pathmanandavel

Notes Dora Lush Basic Science Research Scholarship