Identification and targeting of a potent NK cell “checkpoint” in tumour immunity [ 2017 - 2020 ]

Research Grant

[Cite as]

Researchers: A/Pr Nicholas Huntington (Principal investigator)

Brief description Cancer must evade detection by the immune system in order to develop. Natural Killer (NK) cells can detect and kill cancer cells. We have discovered a potent "checkpoint" in the NK cell activation pathway that desensitizes NK cells to growth factors and switches off their activation and killer function. When this checkpoint is inhibited, NK cells become hyper-activated and prevent most types of cancer metastasis in mice. Targeting this checkpoint in humans could revolutionise cancer therapy

Funding Amount $AUD 481,731.62

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF

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