Identification of a plasma factor of remote ischemic preconditioning and its effect on the proteome after heart surgery [ 2010 - 2012 ]

Research Grant

Researchers: Prof Igor Konstantinov (Principal investigator) ,  A/Pr Michael Cheung ,  A/Pr Vera Ignjatovic ,  Dr Norihiro Oka ,  Prof Paul Monagle
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Brief description Heart surgery with the heart placed into arrest causes inflammation and tissue damage due to interrupted circulation. We know that prior brief interruption and restoration of blood supply called remote ischemic preconditioning (IPC) can protect heart and lungs against damage. Our previous studies indicate that IPC involves a circulating factor that protects the tissue by optimizing energy preservation. This knowledge can be applied to organ transplants, protection from stroke and heart attack.

Funding Amount $AUD 385,197.44

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant