Identification of novel mechanisms governing stage-specific regulation of the human globin genes [ 2008 - 2010 ]

Research Grant

Researchers: Prof Stephen Jane (Principal investigator) ,  A/Pr Don Lavelle ,  A/Pr Ian Street ,  Dr Quan Zhao ,  Prof John Cunningham

Brief description Hemoglobin is the major protein in red blood cells and is essential for the transport of oxygen from the lungs to the tissues. The disorders of hemoglobin production are the commonest genetic diseases worldwide. These diseases can be markedly improved with elevation of the form of hemoglobin produced by the developing embryo, fetal hemoglobin. We have identified key factors important for fetal gene expression. Our goal is to translate these findings into therapies for the hemoglobin disorders.

Funding Amount $AUD 481,826.11

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant