grant

Identification of interferon stimulated genes that limit HCV replication and predict therapeutic outcome [ 2008 - 2010 ]

Also known as: Host genes that control HCV replication and predict treatment response

Funded by National Health and Medical Research Council
Managed by The University of Adelaide
Managed by University of Adelaide
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/508088]

Researchers: A/Pr Michael Beard (Principal investigator) ,  Dr Karla Helbig ,  Prof Eric Gowans

Brief description The only treatment for hepatitis C is Interferon-ribavirin combination therapy. Interferon works by stimulating the liver cells to produce antiviral proteins that can control hepatitis C virus replication, however we do not know which proteins are responsible. The aim of this proposal is to identify those proteins that can limit HCV replication using both a laboratory based and clinical approach and to identify markers that will predict treatment outcome.

Funding Amount $AUD 389,224.94

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Antiviral | Applied Immunology (Incl. Antibody Engineering, Xenotransplantation and T-Cell Therapies) | Biomedical and Clinical Sciences | Gene Expression | Hepatitis C Virus | Host antiviral response | Immunology | Interferon | interferon therapy HCV | liver disease | microarray |
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