Identification of host restriction factors that block respiratory virus infection [ 2018 - 2021 ]

Research Grant

Researchers: Prof Patrick Reading (Principal investigator) ,  Dr Sarah Londrigan

Brief description Following inhalation, respiratory viruses can infect and grow in airway epithelial cells. Although immune cells such as macrophages are also susceptible to infection, this is generally abortive and new viruses are not released. This project will identify proteins induced in macrophages that block respiratory viruses and prevent their spread in the airways. We will also define mechanisms by which some virulent strains overcome this block to grow in macrophages.

Funding Amount $AUD 970,294.58

Funding Scheme Project Grants

Notes Standard Project Grant