Is Hypoxia Inducible Factor 2 the Trigger of the Angiogenic Switch and a Driver of Disease Progression in Myeloma? [ 2010 - 2012 ]

Research Grant

Researchers: Prof Andrew Zannettino (Principal investigator) ,  A/Pr Daniel Peet ,  Prof Jean-Pierre Levesque ,  Prof Luen To ,  Prof Stan Gronthos

Brief description Multiple myeloma (MM) is a fatal cancer of plasma cells (PC). PC migrate to the bone marrow, which compared with other organs is low in oxygen (hypoxic). In response to this hypoxia, the cancer cells turn on the expression of genes called hypoxia-inducible factors (HIF). HIFs activate the expression of genes that encourage blood vessel formation, which in turn stimulates greater tumour growth and disease progression. This proposal will investigate the role of HIFs in the progression of MM.

Funding Amount $AUD 605,096.28

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant