Hypothalamic oxexin-synthesizing neurons regulate the ultradian Basic Rest-Activity Cycle (BRAC); studies in transgenic rats and mice [ 2013 - 2015 ]

Also known as: Orexin neurons integrate behaviour and autonomic function

Research Grant

[Cite as]

Researchers: E/Pr William Blessing (Principal investigator) ,  Dr Youichirou Ootsuka

Brief description In the hypothalamus region of the brain there is a group of neurons that synthesize a neuropeptide messenger called orexin. In humans, malfunction of orexin neurons results in narcolepsy (abnormal sleepiness) and in disordered metabolism resulting in obesity. Our experiments, conducted in genetically-modified rats and mice, will elucidate the manner in which the orexin neurons integrate our behaviour (eg eating) with our physiological state (eg body and brain temperature, arterial blood pressure).

Funding Amount $AUD 588,418.38

Funding Scheme Project Grants

Notes Standard Project Grant

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