Hypospadias and control of urethral closure [ 2014 - 2016 ]

Research Grant

Researchers: Prof Marilyn Renfree (Principal investigator) ,  A/Pr Andrew Pask ,  Dr Hongshi Yu ,  E/Pr Geoffrey Shaw ,  E/Pr Jean Wilson

Brief description Hypospadias, is a common defect, in which the urethra opens abnormally along the shaft of the penis not at the tip. It affects 1 in every 125 boys born in Victoria each year. However, the cause(s) of over two-thirds of these cases cannot be explained. Our studies using marsupials show that this process is mediated by a hormone (5alpha-androstanediol), with previously undetermined physiological function. This study will provide novel data on the interactions of the genes and hormones that result in defects of penile development.

Funding Amount $AUD 732,052.77

Funding Scheme Project Grants

Notes Standard Project Grant