Human RIPC-derived Regulatory Molecules for Cardioprotection against Ischemic and Cardiopulmonary Bypass Injury [ 2015 - 2017 ]

Research Grant

Researchers: A/Pr Salvatore Pepe (Principal investigator) ,  A/Pr Joseph Smolich ,  Prof Igor Konstantinov

Brief description Our previous work indicates that evoked human blood borne factors confer protection against injury, due to loss of blood flow in heart muscle, when a brief stress is remotely applied to a limb (remote ischemic preconditioning). We have identified these proteins that appear to activate genetic and metabolic regulation of adaptive cell survival processes. We will now test their individual and combined capacity, efficiency and mechanisms of protection in the heart using cell and clinical models.

Funding Amount $AUD 642,083.81

Funding Scheme Project Grants

Notes Standard Project Grant