The human papilloma virus oncoprotein E7 degrades the retinoblastoma protein by enhancing calpain activity [ 2006 - 2008 ]

Research Grant

Researchers: Prof Andreas Suhrbier (Principal investigator) ,  Dr Grant Darnell

Brief description Cervical cancer is the second most prevalent cancer worldwide and the fifth leading cause of cancer deaths in women. Approximately 470,000 new cases are diagnosed annually. In most cases cervical cancer is thought to be caused by certain types of the human papillomavirus. Human papillomavirus makes a seies of proteins that cause the destruction of key host proteins in the cells they infect. This destruction is central to the formation of cervical cancer. We have recently discovered that we can prevent this destruction and rescue the key host proteins using inhibitors of the enzyme calpain. Here we seek to determine whether calpain inhibitors could find application in the treatment of human papillomavirus associated cancer.

Funding Amount $AUD 258,067.77

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant