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Human cytomegalovirus gene expression and functions during latent infection and reactivation [ 2009 - 2012 ]

Also known as: How does cytomegalovirus persist in the human population

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/570962]

Researchers: A/Pr Barry Slobedman (Principal investigator) ,  Prof Edward Mocarski

Brief description Human cytomegalovirus has the ability to hide in the body in a latent form for the life of the host. However, the virus can awaken (reactivate) from its latent state, producing new infectious virus and disease. It is in immunosuppressed people such as transplant patients that reactivation from latency causes significant morbitity and mortality, yet the latent infection remains very poorly understood. This project will identify and define the functions of viral genes that facilitate latency.

Funding Amount $AUD 789,473.74

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Allogeneic transplantation | Anti-latency drugs | Applied Immunology (Incl. Antibody Engineering, Xenotransplantation and T-Cell Therapies) | Biomedical and Clinical Sciences | Cytomegalovirus induced graft versus host disease | Human cytomegalovirus | Human cytomegalovirus pneumonia | Immunology | Latent infection | Myeloid progenitor cells | Viral gene expression and function during latency |
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