Host genes controlling Flavivirus infection: new insights and application for developing highly effective Kunjin replicon-based Ebola vaccine [ 2016 - 2018 ]

Research Grant

Researchers: Prof Alexander Khromykh (Principal investigator) ,  Prof Andreas Suhrbier

Brief description The applications is aimed at identifying new host genes controlling infection with West Nile virus and other medically important flaviviruses such as dengue and Japanese encephalitis. For this, we will use novel in vivo RNAi screening approach with virus libraries encoding artificial microRNAs (amirs) targeting whole mouse genome. We will then apply amiR technology to produce highly effective Kujniin replicon-based Ebola vaccine candidate that has shown promising results in trails in primates.

Funding Amount $AUD 759,113.70

Funding Scheme Project Grants

Notes Standard Project Grant