Hormone Transport by Alpha-2-Macroglobulin: Novel Roles in Regulating Hormone Activity [ 2017 - 2019 ]

Research Grant

Researchers: Prof Des Richardson (Principal investigator) ,  A/Pr Deborah Trinder ,  Dr Michael Li-Hsuan Huang ,  Dr Richard Clark ,  Prof V. Nathan Subramaniam

Brief description Alpha-2-macroglobulin is a large protein in the blood known to bind and transport numerous hormones in the circulation. Our previous studies published in BLOOD (2009) and JBC (2013) have discovered an important role for this molecule in the transport and regulation of a peptide hormone. The studies proposed in this application have important implications for understanding new roles of alpha-2-macroglobulin in hormone binding and regulating the activity of hormones in disease states.

Funding Amount $AUD 617,262.71

Funding Scheme Project Grants

Notes Standard Project Grant