grant

Homeodomain Nkx2-5-dependent negative feedback loop important in heart development and congenital heart disease [ 2009 - 2013 ]

Also known as: Genetic pathways in heart development and congential heart disease

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/573703]

Researchers: Prof Richard Harvey (Principal investigator) ,  Prof Sally Dunwoodie

Brief description Congenital heart disease (CHD) is the cause of most deaths in children in the first year of life. We have identified a genetic pathway important for both normal cardiac development and CHD that involves the cardiac transcription factor Nkx2-5. This pathway controls a transition in embryos between cardiac cell specification and expansion. We will now explore the biochemical and genetic mechanisms underlying this pathway to help us understand CHD and identify its causative genes.

Funding Amount $AUD 1,330,245.60

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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