grant

Histone H3.3 dynamics at the telomere in pluripotent embryonic stem cells [ 2008 - 2010 ]

Also known as: Defining telomere chromatin and organizational structure in embryonic stem cells and during cellular differentiation

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/491242]

Researchers: A/Pr Lee Wong (Principal investigator) ,  Prof Andy Choo

Brief description The telomere is required for the protection of the chromosome ends. Telomere loses its repeat during each cell division, so telomere shorthening is one of the mechanisms underlying organismal aging as critically short telomeres induce chromosome instability and cell death. Defective telomeres can also result in genetic diseases and development of cancers. Here, we propose to study the mechanism that operates to ensure continual telomere renewal without senescence in embryonic stem cells.

Funding Amount $AUD 571,977.75

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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