Histone Demethylase KDM6A is a novel target for treating craniosynostosis in children with Saethre-Chotzen Syndrome [ 2018 - 2020 ]

Research Grant

Researchers: Prof Stan Gronthos (Principal investigator) ,  Prof Peter Anderson

Brief description Children with Saethre-Chotzen syndrome exhibit premature fused coronal sutures, and other skull/ skeletal malformations. Surgical intervention is the only treatment option to ensure optimal cognitive and skeletal development. Our studies have identified a candidate molecular pathway that regulates bone formation by cranial bone cells from these patients. Targeting this key molecular regulator with chemical inhibitors will help prevent the premature fusion of cranial sutures.

Funding Amount $AUD 556,537.95

Funding Scheme Project Grants

Notes Standard Project Grant