High-Throughput Screening of the Genome and Proteome in Postmortem CNS from Subjects with Schizophrenia [ 2002 - 2004 ]

Research Grant

Researchers: Prof Brian Dean (Principal investigator) ,  A/Pr Elizabeth Thomas

Brief description Schizophrenia is a serious psychiatric illness that effects ~1% of the Australia population. The underlying pathology of the illness remains unknown. This application seeks funding to use new technologies to screen approximately 60% of the expressed human genome and proteome to determine which genes are being differentially expressed in two regions thought to be important in generating the symptoms of the illness, the frontal cortex and hippocampus. This project will generate a large amount of data, however by comparing the data from subjects with schizophrenia to that from control subjects and subjects with bipolar disorder who were psychotic and being treated with antipsychotic drugs close to death will allow us to identify changes that are specific to schizophrenia. Genes that are expressing different levels of mRNA and protein will become prime targets for future investigations as they are likely to be central to the pathology of the illness.

Funding Amount $AUD 553,190.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant