High-Throughput Discovery of Synergistic Drug Combinations for Metastatic Colorectal Cancer [ 2015 - 2019 ]

Research Grant

Researchers: A/Pr Oliver Sieber (Principal investigator) ,  A/Pr Ian Street ,  Dr Jayesh Desai ,  Prof John Mariadason

Brief description Treatment outcomes for patients with metastatic bowel cancer remain poor, with most tumours developing resistance within 24 months. A key problem is that cancers are genetically diverse, with some cells inevitably resistant to any given treatment. This study aims to discover effective drug combinations targeting distinct essential tumour cell functions through robotics-based pairwise testing of known drugs on bowel cancer cell lines representing the genetic diversity of the disease.

Funding Amount $AUD 1,526,568.09

Funding Scheme Project Grants

Notes Standard Project Grant