Helping stroke physicians choose who to thrombolyse - the "Targeting Optimal Thrombolysis Outcomes" (TOTO) study [ 2015 - 2019 ]

Research Grant

Researchers: Dr Elizabeth Holliday (Principal investigator) ,  A/Pr Jonathan Sturm ,  A/Pr Lisa Lincz ,  Dr Andrew Bivard ,  Prof Jane Maguire
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Brief description Thrombolysis using alteplase is one of the most effective treatments for stroke but is currently used in only 5% of stroke cases. A major barrier is a lack of tools to identify who will benefit from treatment, or who might have a major adverse event. In this study we will develop a clinical decision rule based on clinical data, advanced CT imaging, and blood biomarkers to help identify those who will benefit and those likely to bleed, to encourage wider use of this treatment in acute stroke.

Funding Amount $AUD 1,073,140.33

Funding Scheme Project Grants

Notes Standard Project Grant