Hedgehog Signalling in Spermatogenesis [ 2012 - 2015 ]

Research Grant

Researchers: Prof Katherine Loveland (Principal investigator) ,  Prof Eileen Mclaughlin

Brief description Male fertility requires sufficient production of healthy sperm in the testis. We discovered that cells in the adult testis communicate via the Hedgehog (Hh) signalling pathway as sperm develop. We propose to use a highly specific drug to inhibit Hh activity in order to delineate the precise steps in sperm production affected by Hh signalling. We will study the importance Hh in maintenance of spermatogonial stem cells and create mouse models to learn how it is controlled.

Funding Amount $AUD 523,842.47

Funding Scheme Project Grants

Notes Standard Project Grant