Harnessing Extracellular Matrix Remodelling by Cancer-Associated Fibroblasts to Increase T Cell Infiltration of Solid Tumours [ 1/1/2021 - 12/31/2024 ]

Research Grant

Brief description The ability of killer T cells to find and eliminate tumour cells is the basis for adoptive transfer immunotherapies, which thus far only work well with blood-borne cancers. There is limited success with solid tumours, which T cells do not readily infiltrate, notably because of remodelling by fibroblasts. We have discovered that T cells migrate in tunnels dug in the tumour matrix by fibroblasts. Here, we will harness this discovery to improve tumour infiltration and rejection of solid tumours.

Funding Amount $923,407

Funding Scheme Ideas Grants

Chief Investigator Dr Maté Biro

Notes Ideas Grants