Haematopoietic Stem Cell glycome regulates outcome of niche interactions [ 2015 - 2018 ]

Research Grant

Researchers: A/Pr Ingrid Winkler (Principal investigator) ,  Prof Jean-Pierre Levesque ,  Prof John Rasko

Brief description Hematopoietic stem cells (HSC) reside in the bone marrow (BM) and make all the cells of the blood system. We have found a factor in the BM which when blocked, puts normal HSC to sleep helping them survive chemotherapy. This means cancer patients should suffer less side-effects from their therapy. This factor also helps leukaemia stem cells (LSC) resist chemotherapy. Inhibitors may a) reduce patient mortality caused by chemotherapy and b) sensitise LSC to chemotherapy enabling long-term cure.

Funding Amount $AUD 913,729.46

Funding Scheme Project Grants

Notes Standard Project Grant