H2A.Z acetylation: Deregulation of enhancer activity and 3D chromatin in prostate cancer [ 2018 - ]

Research Grant

Researchers: Prof Susan Clark (Principal investigator) ,  Dr Fatima Valdes Mora

Brief description DNA is not linear but packaged in the cell nucleus in a three-dimensional (3D) structure in such a way that distal regulatory regions can interact to control gene expression. Our new data suggests that a chemical modification of the histone variant H2A.Z plays a critical role in the formation of the 3D chromatin structure. This project is aimed to dissect the role of H2A.Z in prescribing 3D structure, which will provide a more precise understanding of gene deregulation in cancer.

Funding Amount $859,350.00

Funding Scheme Project Grants

Notes Standard Project Grant