Granzymes as regulators of inflammation [ 2010 - 2012 ]

Also known as: Novel mechansims of inflammation amplified by lymphocytes

Research Grant

[Cite as]

Researchers: Prof Mark Smyth (Principal investigator) ,  Dr Daniel Andrews

Brief description Inflammatory processes are normally regarded as being initiated and maintained through the activities of white blood cell macrophages. We propose to explore the role of lymphocyte delivery of protease molecules termed granzymes in inflammation. Our preliminary data has demonstrated a novel paradigm involving amplification of septic shock through the activity of granzymes. We now wish to exlore these interactions at a cellular and biochemical level as a means to better understand inflammation.

Funding Amount $AUD 675,309.40

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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