GPER pharmacotherapy in acute stroke [ 2015 - 2018 ]

Research Grant

Researchers: Prof Christopher Sobey (Principal investigator) ,  A/Pr Thiruma Arumugam ,  Prof Grant Drummond

Brief description This project will test whether activators of a novel estrogen receptor (GPER) can limit brain injury and functional deficits after stroke in mice. Part of the work will evaluate two drugs currently in clinical use for chronic conditions – tamoxifen and estradiol – as potential therapies for use in acute stroke. We will study the therapeutic time window of several drugs over up to a week after stroke, and identify key mechanisms underlying the protection by these GPER drugs.

Funding Amount $AUD 881,743.13

Funding Scheme Project Grants

Notes Standard Project Grant