grant

Ghrelins novel neuroprotective effects in Parkinsons disease are mediated by AMP-activated protein kinase (AMPK). [ 2009 - 2011 ]

Also known as: Ghrelin prevents Parkinsons disease: Implications for obesity promoting neurological disorders.

Funded by National Health and Medical Research Council
Managed by Monash University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/546131]

Researchers: A/Pr Zane Andrews (Principal investigator)

Brief description Studies show that body mass index, midlife adiposity and diabetes are associated with Parkinson's disease (PD). During obesity there is a dramatic change in nutritional information, such as hormones, sugars and fats, carried in the blood. This proposal explores how this altered nutritional information in obesity kills the brain cells associated with PD. It will examine how ghrelin, a metabolic hormone inversely related to obesity, influences and protects brain cell activity in models of PD.

Funding Amount $AUD 400,885.04

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant

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Subjects
Biomedical and Clinical Sciences | Body weight regulation | Diabetes | Medical Infection Agents (Incl. Prions) | Medical Microbiology | Neurological disorders | Obesity | Parkinson's disease | effects of energy metabolism on Parkinson's disease | metabolic neuroscience | neuroendocrinology | role of obesity in the pathogenesis of neurological disease |
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ACN 633 798 857